Abstract
Ultraviolet light damages DNA by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism. This damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision repair in humans. The work leading to these results is presented by Aziz Sancar in his Nobel Lecture.
Keywords:
Maxicell method; circadian clock; cryptochrome; nucleotide excision repair; photoreactivation.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MeSH terms
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Adenosine Triphosphatases / metabolism*
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Cryptochromes / metabolism
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DNA Repair*
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Deoxyribodipyrimidine Photo-Lyase / chemistry
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Deoxyribodipyrimidine Photo-Lyase / genetics
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Deoxyribodipyrimidine Photo-Lyase / metabolism*
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Deoxyribonucleases / metabolism*
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Escherichia coli / enzymology
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Escherichia coli / metabolism
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Humans
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Polymorphism, Single Nucleotide
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Pyrimidine Dimers / chemistry
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Pyrimidine Dimers / metabolism
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Ultraviolet Rays
Substances
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Cryptochromes
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Pyrimidine Dimers
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Deoxyribonucleases
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Adenosine Triphosphatases
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Deoxyribodipyrimidine Photo-Lyase